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KMID : 0921620090390030145
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Journal of Bacteriology and Virology
2009 Volume.39 No. 3 p.145 ~ p.157
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Activation of Innate Immune System During Viral Infection: Role of Pattern-recognition Receptors (PRRs) in Viral Infection
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Jun Eun-Jung
Kim Yoo-Kyum
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Abstract
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Innate immunity and adaptive immunity are two major immune responses against pathogens. Innate immunity is responsible for the immediate immune response to pathogens. Pattern-recognition receptors (PRRs) play an important role in innate immune response. PRRs recognize regular patterns of molecule structure known as pathogen-associated molecular patterns (PAMPs). Among the PRRs, Toll-like receptors (TLRs), RIG-I-like receptors (RLRs), and DNA-dependent activator of interferon regulatory factors (DAI) display key roles in response to viral infections. This article reviews how viral infections activate PRR-PAMP signal pathways and how viruses evade immune responses elicited by PRR signal pathways.
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KEYWORD
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Innate immunity, Viral infection, Toll-like receptor, RIG-I-like receptor, PAMP
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